Category: Post & News

Previous Post Increasing Chemotherapy Effectiveness with Oleanolic Acid from Grapes Post & News shro December 30, 2024 Newswise — Researchers describe a new potential role for Oleanolic Acid as a modulator of the DNA damage response following Camptothecin treatment. Administration of Oleanolic Acid in combination with Camptothecin for cancer chemotherapy may reduce the amount of drug needed and increase the effectiveness of treatment. The findings are part of a novel research program focused on identifying new molecules for cancer therapy derived from natural extracts. The study titled, “Oleanolic Acid Modulates DNA Damage Response to Camptothecin Increasing Cancer Cell Death,” was published last week in the International Journal of Molecular Sciences (IJMS). The research group is led by Prof. Antonio Giordano, M.D., Ph.D., Director of the Sbarro Institute for Cancer Research and Molecular Medicine at Temple University, Professor of Pathology at the University of Siena, and Founder of the Sbarro Health Research Organization (SHRO), along with Dr. Luigi Alfano from the Istituto Nazionale Tumori Fondazione Pascale, Naples, Italy. Researchers working with SHRO and Giordano have been responsible for numerous groundbreaking discoveries in molecular biology and precision medicine, including capsaicin’s potential to enhance mesothelioma treatment, a study about the role of CDK9 in oncology, and a genetic target to reduce blood vessel growth in glioblastoma tumors. In this new study, Oleanolic Acid was identified in a grape pomace extract using Nuclear Magnetic Resonance (NMR), revealing a significant effect on the viability of cancer cell lines when combined with a chemotherapeutic drug. The addition of Oleanolic Acid acts as an additive compound with Camptothecin, reducing the required concentration of the chemotherapeutic drug compared to Camptothecin alone. Moreover, Oleanolic Acid does not affect cell viability at the concentrations used in these experiments. “This is an important discovery for our group, highlighting the potential of natural extracts as a source of molecules for cancer therapy,” says Alfano. “Use of Oleanolic Acid may allow us to reduce the Camptothecin drug concentration needed to get the desired anti-cancer result,” says senior author Giordano. “Lower doses of chemotherapy suggests the possibility of reducing the side effects associated with cancer treatment, making the experience more tolerable for patients.” Professor Antonio Giordano, M.D., Ph.D., is the creator and head of the Sbarro Health Research Organization, located at Temple University‘s College of Science and Technology in Philadelphia. Stay connected with him through his various social media platforms, including Facebook, LinkedIn, Twitter, and Instagram

Attentional Focus Importance of Silence Productivity and Focus Antonio Giordano Researchers need to take time for themselves and detach themselves from the flow of information. Attentional Focus Importance of Silence Productivity and Focus Antonio Giordano Researchers need to take time for themselves and detach themselves from the flow of information. Previous Post Attentional Focus Importance of Silence Productivity and Focus Antonio Giordano Post & News shro December 18, 2024 Attention and concentration are fundamental for individual and group performance in every area of human expression. Thus, silence or detachment from the flow of data and information is functional in achieving objectives and purposes.   The lack of attention compromises the flow of research, especially connected with the use of e-mail and technological devices, telephone calls, and work meetings as in fact all these things often force the researcher to interrupt a project and quickly “shift” the attention to another task.   The attentional focus of a person, in any work environment, can vary within a two-dimensional space. There are 4 styles of concentration, interaction and attention, concentration and information processing: a conscious style, in which each acts quickly and instinctively to environmental stimuli. a strategic style, which is centered on a broad and attentive focus oriented towards the analysis and creation of effective strategies; ⁠a systematic style, in which the individual is engaged in the systematic repetition of information necessary to complete the task; ⁠a focused style, characterized by a narrow focus of attention that tends to carry out a mathematical or scientific procedure. In all styles, silence is essential, or at least the possibility of thinking, in an environment where background noises or voices do not disturb the programming or data processing, giving the possibility of thinking about the problem or question continuously. Thus, it is important to isolate oneself even for just a few hours a day, to be able to process the data collected and put it to good use. Certainly, the presence of instant messaging, social media, and email has facilitated the transmission of information and accelerated progress, allowing even at a distance, as in the case of calls or meetings, to interact with working groups that are not in the same Institute. On the other end, this progress has exposed scientists, professors, and researchers to continuous visual and interactive stimuli that slow down their concentration.   A recent publication in Nature has focused on the need for concentration, also aided by relaxation and mentalization techniques. If on one hand, “availability” has made us globally interconnected, on the other hand, the human mind needs time to concentrate and reset information, “clean up” all unnecessary data not aimed at a certain result. Briefly, the first and foremost need of the mind of every individual and scientist is the ability to isolate even for a limited time as in fact time and silence are essential to deconstruct, create new paths, and choose, through the exact analysis of the question, the best strategy. For those who seek, analyze, and transform the truth, silence is not empty but full of answers. Professor Antonio Giordano, M.D., Ph.D., is the creator and head of the Sbarro Health Research Organization, located at Temple University‘s College of Science and Technology in Philadelphia. Stay connected with him through his various social media platforms, including Facebook, LinkedIn, Twitter, and Instagram

Previous Post SPORT GENOMICS – Giordano: “On the Field to Prevent Illnesses Like Bove’s with Genetic Predictions, but 20% of Life Events Remain an Unpredictable Enigma. Post & News shro December 18, 2024 The Sport Genomics project is working to prevent illnesses like those faced by Fiorentina footballer Edoardo Bove, to whom we extend our deepest support and solidarity. Despite advancements in genetic predictions, it’s important to acknowledge that 20% of life events remain an unpredictable enigma—true acts of destiny.   Antonio Giordano, oncologist, pathologist, and President of the Sbarro Institute at Temple University, spearheads the Sport Genomics initiative. This precision medicine project focuses on the early identification of genetic vulnerabilities that could predispose athletes to illnesses and injuries. By using genetic screening from saliva samples, the project aims to implement personalized training programs and dietary-nutritional strategies tailored to individual needs.   To date, over 100 saliva samples have been collected in collaboration with Fiorentina AC and are currently under analysis. Additional agreements have been made with Asti Futsal (Serie A five-a-side football) and Real Società Ginnastica di Torino’s basketball section. These partnerships aim to expand the pool of analyzed samples, particularly from youth athletes of both genders in the Piedmont region.   In parallel, another precision medicine initiative, Cancer Deflect, offers the possibility of early lung cancer diagnosis with enhanced long-term prognostic capabilities. This project builds on prior work between Rigenera and the University of Siena, led by Professor Giordano. Using the HBW surgical device, researchers identify a subpopulation of cancer stem cells within lung tumor biopsies, which can then undergo detailed molecular analysis.   Through these cutting-edge approaches, both projects strive to advance health and well-being in sports and medicine, while acknowledging the limits of science in navigating the unpredictable aspects of life. Professor Antonio Giordano, M.D., Ph.D., is the creator and head of the Sbarro Health Research Organization, located at Temple University‘s College of Science and Technology in Philadelphia. Stay connected with him through his various social media platforms, including Facebook, LinkedIn, Twitter, and Instagram

Peregrine falcon Heavy metals Wildlife conservation Environmental health Ecosystem Post & News shro December 18, 2024 Newswise — Philadelphia, Pennsylvania – Exposure to heavy metals compromises immune functions and reduces reproductive success in the peregrine falcon (Falco peregrinus), according to a new paper published by researchers working with the Sbarro Health Research Organization (SHRO) at Temple University in collaboration with the veterinary research group of the Department of Health Sciences at Magna Graecia University of Catanzaro, Italy. Furthermore, persistent chemicals like brominated flame retardants threaten their populations, underscoring the importance of these majestic raptors in monitoring pollution and highlighting the broader implications for wildlife, ecosystems, and human health.   The peregrine falcon, renowned for its unparalleled speed and hunting prowess, emerges as a vital sentinel species for assessing hazardous toxins and exemplifying the intricate balance between human progress and environmental health. This apex predator, occupying a high position in the food chain, accumulates pollutants from its prey, offering critical insights into ecosystem integrity and contamination levels and emphasizing the urgent need for monitoring.    Peregrine falcons have long been recognized for their susceptibility to environmental pollutants, making them an indispensable bioindicator. Historical declines in their populations, driven by the use of organochlorine pesticides such as DDT, spotlighted the devastating impact of human activities on wildlife. While regulatory measures facilitated their remarkable recovery, new challenges emerge as ecosystems contend with a growing variety of contaminants.    Prof. Antonio Giordano and Dr. Giovanna Liguori have emphasized the critical role peregrine falcons play in studying the impact of pollution, as described in the research review, “Understanding Environmental Contamination Through the Lens of the Peregrine Falcon (Falco peregrinus),” published this month in the journal Environments.   “Our review highlights that peregrine falcons might serve as valuable models for investigating the impact of environmental contaminants on human health,” says Antonio Giordano, M.D., Ph.D., Founder and Director of SHRO and Professor at Temple University. “Given that numerous chemical substances detrimental to wildlife also pose risks to humans, monitoring peregrine falcon populations can contribute to predicting and mitigating contaminant-related diseases (e.g. neoplasia etc.). By analyzing contaminant levels in peregrine falcon tissues, researchers could assess potential risks to human populations inhabiting the same regions.”   “Peregrine falcons teach us about the interconnectedness of nature and human activity,” says Giovanna Liguori, Ph.D., Doctor of Veterinary Medicine with the Local Health Authority of Foggia, Italy. “Every pollutant found in their systems tells a story about our environment. By investing in advanced monitoring technologies and global collaboration, we might create a safer and healthier world for all species. This is not just about conserving wildlife; it’s about securing our shared future.” Advanced technologies, including molecular biomarkers and remote sensing, promise to revolutionize data collection and analysis. These tools can trace pollutant origins, map dispersal, and illuminate biological impacts at the cellular level. The integration of such cutting-edge methodologies will enhance conservation strategies, safeguarding not only peregrines but also the ecosystems they inhabit.   Positioned at the nexus of human, animal, and environmental health, the peregrine falcon exemplifies the interconnectedness underscored by the One Health approach. By studying the effects of pollutants on these birds, researchers can draw parallels to human health risks, fostering collaboration between ecotoxicologists, public health experts, and conservationists. Notably, innovative research into semen biomarkers within peregrine falcons holds promise for understanding reproductive health impacts across species. Such studies could pave the way for more comprehensive monitoring of environmental toxins and their cumulative effects on biodiversity and human well-being.   To unlock the full potential of peregrine falcons as environmental sentinels, future research must: Broaden the scope of monitoring programs to encompass emerging contaminants.  Leverage advanced analytical techniques like genomics and proteomics for deeper insights.  Pursue longitudinal studies to track chronic exposure effects on population dynamics.  Strengthen global collaborations to address transboundary pollution challenges.  Professor Antonio Giordano, M.D., Ph.D., is the creator and head of the Sbarro Health Research Organization, located at Temple University‘s College of Science and Technology in Philadelphia. Stay connected with him through his various social media platforms, including Facebook, LinkedIn, Twitter, and Instagram

American Scientific Research: A Heritage for All- Antonio Giordano Post & News shro December 18, 2024 Democratic and Republican leaders must recognize the importance of scientific research and support it with adequate policies and funding. In an age of political polarization, it is important to remember that scientific research is above party lines. It does not belong to Democrats or Republicans. Science is a shared heritage and a collective good above ideological division. American scientific research, renowned for its groundbreaking discoveries and innovations, has the power to improve lives across the spectrum of political affiliations. Science has always been a unifying force. Its discoveries have no political boundaries, and its technological innovations can benefit humanity as a whole through important medical advances, such as vaccines and gene therapies, which have saved millions of lives. These remarkable achievements stem from years of rigorous study and collaborative efforts among scientists of diverse nationalities and political orientations. Sharing scientific knowledge is vital for progress. Research cannot flourish in an environment of isolation or secrecy. Transparency and collaboration form the foundation of science. When results are easily accessible, they can be verified, replicated, and refined to drive advancement. American scientific research faces significant challenges, including funding, regulation, and public perception issues. Overcoming these challenges requires collective effort and a shared vision. Political leaders, regardless of their affiliations, must acknowledge the critical role of science and support research through sound policies and adequate funding. In today’s interconnected world, international collaboration is indispensable. The COVID-19 pandemic has underscored the importance of global cooperation in scientific research. Addressing global challenges—such as climate change, infectious diseases, and food security—demands a united effort. American scientific research is not a partisan issue: it is a cornerstone of human progress. It is a legacy that belongs to everyone and must be supported, shared, and cherished. Through collective commitment and a shared vision, we can confront future challenges and create a better world for generations to come. Professor Antonio Giordano, M.D., Ph.D., is the creator and head of the Sbarro Health Research Organization, located at Temple University‘s College of Science and Technology in Philadelphia. Stay connected with him through his various social media platforms, including Facebook, LinkedIn, Twitter, and Instagram