SHRO’s congrats to the winners of the 2025 Nobel Prize in Physiology or Medicine

Congratulations to the winners of the 2025 Nobel Prize in Physiology or Medicine!
On behalf of the Sbarro Health Research Organization – SHRO Italy, we congratulate Mary E. Brunkow, Frederick J. (Fred) Ramsdell, and Shimon Sakaguchi, awarded the Nobel Prize “for discoveries on peripheral immune tolerance” and on the role of regulatory T cells (Tregs) in keeping the immune system in balance.

Thanks to these discoveries, oncologists have: gained a better understanding of how tumors “switch off” the immune system through Tregs that suppress anti-cancer responses; developed strategies to bypass or block this brake; introduced new biomarkers — including FOXP3 — to identify patients with a highly immunosuppressive tumor microenvironment and to guide therapeutic decisions.

In short, this knowledge has made immuno-oncology therapies more personalized and effective.
As an Italian–American organization committed to translational research, SHRO renews its commitment to transforming basic discoveries into tangible benefits for patients, training young researchers, and strengthening collaborations between Italy and the USA.

Congratulations to the 2025 Nobel laureates, and thanks to the scientific community that builds progress every day.