AIDS-Related Lymphoma

Definition

AIDS-related lymphoma is a group of aggressive cancers that originate in the lymphatic system and occur more frequently in people with HIV or AIDS due to a weakened immune system.

Characteristics

This type of lymphoma often develops rapidly and can affect lymph nodes, the brain, bone marrow, or other organs. Common subtypes include diffuse large B-cell lymphoma and Burkitt lymphoma, both of which are highly aggressive.

Diagnosis and Prognosis

Diagnosis involves imaging, lymph node biopsy, and tests to assess HIV status and immune function. Prognosis depends on the cancer stage, the person’s immune health, and response to HIV therapy. Combination antiretroviral therapy (cART) can improve outcomes significantly.

Treatment

Standard treatment includes chemotherapy, often combined with antiretroviral therapy. In some cases, radiation or targeted therapies may be used. Managing both lymphoma and HIV infection simultaneously is critical for improving survival and quality of life.

Last Revised: 12 May , 2025