Childhood Hodgkin Lymphoma

Definition

Childhood Hodgkin lymphoma is a cancer of the lymphatic system that typically affects teenagers and young adults. It is defined by the presence of Reed-Sternberg cells and is considered one of the most treatable pediatric cancers.

Characteristics

Symptoms include painless swelling of lymph nodes (especially in the neck, chest, or underarms), fever, night sweats, unexplained weight loss, fatigue, and persistent cough or chest pain if the mediastinum is involved.

Diagnosis and Prognosis

Diagnosis involves physical examination, imaging tests like CT or PET scans, lymph node biopsy, and blood tests. Prognosis is excellent, with high cure rates, especially for early-stage disease and patients who respond quickly to initial therapy.

Treatment

Treatment options include chemotherapy, often combined with low-dose radiation therapy. Newer approaches aim to minimize long-term side effects while maintaining high cure rates. Stem cell transplantation may be considered for relapsed or refractory cases.

Last Revised: 12 May , 2025