Transitional Cell Cancer of the Renal Pelvis and Ureter

Definition

Transitional cell cancer of the renal pelvis and ureter is a rare type of cancer that forms in the lining of the renal pelvis (the area of the kidney where urine collects) and the ureter (the tube connecting the kidney to the bladder).

Characteristics

This cancer is similar to bladder cancer and shares risk factors like smoking and exposure to certain chemicals. Symptoms often include blood in the urine, frequent urination, painful urination, and back pain.

Diagnosis and Prognosis

Diagnosis involves urine tests, imaging studies like CT urography, and sometimes ureteroscopy with biopsy. Prognosis depends on tumor size, location, grade, and spread. Early-stage cancers have better outcomes when promptly treated.

Treatment

Treatment options include surgery to remove the tumor, which may involve removing the kidney and ureter (nephroureterectomy), along with chemotherapy or immunotherapy, especially if the cancer is aggressive or has spread.

Last Revised: 12 May , 2025